In 1968, radical feminist Valerie Solanas (Lili Taylor) shot pop-art icon Andy Warhol (Jared Harris) when he ignored the screenplay she wrote. This film traces Solanas's life up to that moment, from childhood abuse to college prostitution to writing the male-bashing "SCUM Manifesto." Taylor won a Special Recognition Award at the Sundance Film Festival for her portrayal of a deranged woman seeking recognition.

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