Bill Denny (George Segal) and Charlie Walters (Elliot Gould) are two compulsive gamblers with nothing in common except incredibly bad luck. But after a chance meeting in a Los Angeles card parlor, they find that they make an unbeatable team. Embarking on a once-in-a-lifetime winning streak, Bill and Charlie bet their way to the plush casino tables of Reno, where they risk it all in a "friendly" little poker game with the reigning world champion.