Based on the Junji Ito horror comic about a vengeful girl who refuses to die, Tomie: Revenge begins when a young woman named Kazue (Hisako Shirata) accidentally runs over a naked girl on a mountain road. When Kazue stops to help, the girl disappears. A year later, Kazue is obsessed with finding the girl -- especially after an investigator tells her about the infamous "Tomie incidents" in which the dead Tomie inhabits other bodies.