Royce (Wes Bentley) and Dexter (Scott Speedman), two hapless stoners appropriately from the town of Weedsville, launch a chain of catastrophic events when they assume their friend Matilda (Taryn Manning) has overdosed on drugs they've stolen from a dangerous dealer. Soon, the slacker duo finds themselves on the run from a gang of vengeful thugs, angry Satanists and, worst of all, a mob of marauding little people -- all in one night.