Ignoring instructions from the pharmaceutical company that funds their research, groundbreaking genetic scientists Elsa (Sarah Polley) and Clive (Adrien Brody) continue with an unorthodox experiment to create a human-animal hybrid, a new life form they dub "Dren" (Delphine Chanéac). When they see their fantastical creation, Clive warns that it should be destroyed, but Elsa refuses -- a decision she'll regret when Dren makes deadly plans of her own.