Forlani's American acting bow came in the TV miniseries JFK: Reckless Youth (1993), but it was her breakthrough role in Mallrats that led to her landing the part of the title character's waitress girlfriend in Basquiat (1996). With a delicate beauty that lends itself to playing downtrodden girlfriends, Forlani soon found herself cast in that mold in a series of films, including Meet Joe Black (with Brad Pitt, 1998) and Mystery Men (1999).
Among Forlani's later films of note are Bobby Jones: Stroke of Genius (2004) and Green Street Hooligans (2005).