Born Dec. 26, 1971, in Bossier City, La., Leto studied filmmaking at the School of Visual Arts in New York before moving to Los Angeles to pursue a career in acting. Leto earned critical acclaim playing the title role in 1997's Prefontaine, followed in quick succession by roles in Girl, Interrupted, American Psycho and David Fincher's Fight Club and Panic Room.
After co-starring in Oliver Stone's big-budget epic Alexander (2004), Leto took on another transformative role, gaining 60 pounds to play assassin Mark David Chapman in Chapter 27.