Tickled by Romano's deadpan delivery, late-night staple David Letterman asked his production company to create a sitcom that would showcase the funnyman's talents. The series -- "Everybody Loves Raymond" (1996-2005) -- became a smash hit, earning the actor three Emmy Awards (in 2002, '03 and '05) along with a slew of other nominations.
Romano debuted on the big screen providing the voice of a woolly mammoth named Manny in Ice Age (2002), reprising the role in Ice Age: The Meltdown (2006). Other noteworthy cinematic efforts include Welcome to Mooseport, Eulogy and the documentary 95 Miles to Go (all 2004).