Throughout the 1990s, Def appeared on TV shows such as "Spin City" and "NYPD Blue." As his rap career took off, so did his big-screen career, and by the beginning of the new decade, he was delivering critically acclaimed performances with supporting roles in films such as Monster's Ball, Brown Sugar, The Italian Job and The Woodsman.
In 2004, Def earned an Emmy nomination for his performance opposite Alan Rickman in Something the Lord Made, and in 2005, he proved his comic chops with a leading role in The Hitchhiker's Guide to the Galaxy.