After small parts in Catch Me If You Can (2002, with Leonardo DiCaprio) and Daredevil (2003), Pompeo found a larger audience portraying Luke Wilson's love interest in the campus comedy Old School (2003) and as a guest star on the final season of "Friends."
But Pompeo cemented her fan base with her turn as titular heroine Dr. Meredith Grey in the hit series "Grey's Anatomy," a part that netted the actress a Golden Globe nod. Pompeo's later cinematic roles include 2005's Life of the Party.