After a handful of television appearances, Khan launched his film career with Deewana (1992), playing the son of rich man who romances a grieving widow. A string of commercial successes followed, earning the actor leading roles in movies such as Dilwale Dulhania Le Jayenge (1995), Kuch Kuch Hota Hai (1998), Chak De! India (2007) and Om Shanti Om (2007).
Khan has also applied his talents to the realm of television game shows, hosting "Kaun Banega Crorepati" (the Indian version of "Who Wants to Be a Millionaire?") and "Kya Aap Paanchvi Pass Se Tez Hain?" (the Indian version of "Are You Smarter Than a 5th Grader?").