Born in New York City Aug. 10, 1959, she first appeared on the silver screen in More American Graffiti (1979) and subsequently in Gorp (1980) and S.O.B. (1981). Arquette's first leading role came in Baby It's You (1983), but it was her supporting turn in Desperately Seeking Susan (1985) that made her a star. Later that year, Arquette played opposite Jeff Goldblum in Silverado. Her body of work includes such diverse movies as Nobody's Fool (1986), Pulp Fiction (1994), Buffalo '66 (1996), The Whole Nine Yards (2000) and Good Advice (2001).
The granddaughter of Cliff Arquette (aka Charley Weaver of "Hollywood Squares" fame), Rosanna is the sister of actors David and Patricia Arquette.