That destiny came quickly: By age 18, Arquette had made her movie debut, and in 1987 she landed her first starring role, in A Nightmare on Elm Street 3: Dream Warriors. During the '90s, Arquette captured the public's attention with a string of successful films, including Ethan Frome, True Romance, Ed Wood, Flirting with Disaster (as Ben Stiller's put-upon wife) and Stigmata. Also during that decade, she married fellow actor Nicolas Cage (a union that's since ended).
In 2005, Arquette was cast in the lead role of the TV drama "Medium," for which she received an Emmy.